Dr. Rong Zhu Gan - Charles E. Foster Chair in Biomedical Engineering and Professor of Mechanical Engineering, Adjunct Professor of Physiology. The research activities in Dr. Gan’s Biomedical Engineering Lab are centered on basic research to understand structures and functions of living systems and applied research to develop new and improved devices and products for medicine and biology. Her current research projects include measurement of sound transmission in normal, diseased, and implanted ears, computational modeling of auditory system, design of implantable hearing devices, and biomechanics of tissues and organs.
Dr. Elizabeth A. Karr - The Karr lab is interested in the regulation of gene expression in microorganisms. Gene expression is of integral importance in biological systems and is regulated by a variety of mechanisms. The Karr lab uses a variety of microbiological, biochemical and structural approaches to unravel regulatory mechanisms in medically and environmentally important organisms.
Dr. Cecil M. Lewis Jr. - Associate Professor of Anthropology, Co-Director of the Laboratories of Molecular Anthropology and Microbiome Research (LMAMR). Dr. Lewis’s research addresses questions concerning the distribution and evolution of human genetic variation – both with respect to the human genome and the human microbiome. To address these questions, he has collected and/or analyzed ancient DNA, genetic data from hypervariable mitochondrial regions, from autosomal functional regions, genome-wide survey of Short Tandem Repeats, and microbial genomes. Research topics include human population history, the evolution of disease associated genetic variation, and the relationship between cultural, environmental and genetic variation.
Dr. Hong Liu - Charles and Jean Smith Chair in Biomedical Engineering, Professor of Electrical and Computer Engineering, Adjunct Professor of Medicine. Dr. Liu’s research interest is in medical imaging. His current projects include phase and phase contrast x-ray imaging, digital mammography, digital radiography, stereo fluoroscopy, and optical and fluorescent imaging devices. He is a fellow of the American Institute of Medical and Biological Engineering (AIMBE) and a fellow of the International Society for Optical Engineering (SPIE). He is also the Chief Editor of the Journal of X-ray Science and Technology.
Dr. Yiqi Luo – Professor of Ecology. Dr. Luo’s research program is designed to study processes and patterns in ecosystem ecology and biogeochemical cycles. Major issues we are addressing include (1) how global environmental changes alter function and structure of terrestrial ecosystems, and (2) how terrestrial ecosystems regulates climate change and chemical composition (such as CO2) in the atmosphere. Our research is aimed at quantifying dynamics of carbon, nutrient, and water resources in ecosystems. We study a variety of ecosystems, including forests, grasslands, deserts, and coastal wetlands.Our laboratory uses both modeling and experimental approaches. With respect of modeling, we focus on development and testing of biogeochemical models at ecosystem and regional scales. Our current efforts are on development of an inverse modeling approach to parameter estimation and model improvement. Our inverse modeling uses data from the Free-Air CO2 Enrichment (FACE) experiment in the Duke Forest, AmeriFlux sites and biometrical measurements.
Dr. Christina Warinner - Assistant Professor of Anthropology, Co-Director of the Laboratories of Molecular Anthropology and Microbiome Research (LMAMR). Dr. Warinner’s research addresses questions concerning the evolution of human diet and the evolution and ecology of the human microbiome. To address these questions, she combines both ancient DNA and modern DNA analyses using high-throughput metagenomic NGS sequencing, as well as proteomic analysis using LC-MS/MS. She has pioneered the investigation of dental calculus (calcified dental plaque), the richest source of ancient biomolecules known in the archaeological record. Her research topics include the evolutionary ecology of periodontal disease, human genetic variation related to nutrition and digestive function, the origins and spread of dairying, and the ancestral state of the human oral and gut microbiomes.
Dr. Xiangming Xiao - Professor at Department of Botany and Microbiology and Center for Spatial Analysis. The Earth Observation and Modeling Facility (EOMF) focuses on geospatial science and technology (remote sensing, global positioning system, geographical information sysetm) and its applications in natural resources, agriculture, forestry, rangeland, biodiverity, ecology, climate, geography, land use and land cover change, and animal and human health. The EOMF hosts global satellite image data to support research and education in monitoring, diagnosis and forecasting of the biosphere in our planet Earth.
Dr. Bin Zheng - Professor of Electrical and Computer Engineering, Oklahoma TSET Cancer Research Scholar at the Peggy and Charles Stephenson Cancer Center. Dr. Zheng’s research field is developing and validating computer-aided detection and diagnosis (CAD) schemes of medical images. The primary purpose of the research is to develop and provide clinicians more reliable and quantitative medical image and signal data analysis tools that have potential to improve efficacy of cancer screening, diagnosis, and prognosis assessment. Current research interest and activities in his CAD laboratory include (1) developing and evaluating breast cancer risk stratification models for predicting risk of women developing breast cancer in near-term (e.g., <5 years after a negative screening examination), (2) optimizing and testing the interactive CAD systems using content-based image retrieval (CBIR) technology, which provide “visual aid” to radiologists in tumor diagnosis and/or classification, (3) investigating and applying new optical and electrical testing methods to detect properties of tumor tissues or cancer cells, which will be used to generate computerized biomarkers for assessment of cancer prognosis.
Dr. Jizhong Zhou - Presidential Professor,
Department of Botany and Microbiology,
Institute for Environmental Genomics. Dr. Zhou is a distinguished R&D staff scientist in microbial genomics and ecology at Oak Ridge National Laboratory in Tennessee. He and his research group are joining OU at the Stephenson Research and Technology Center to form the new Institute for Environmental Genomics. Dr. Zhou is an international research leader in functional genomics analyses of microbial stress responses, energy metabolism, and regulatory networks in several environmentally important microorganisms.
Dr. Tyrrell Conway - The human genome and the genomic inventory of the microflora that human life depends on are complete yet the essence of how commensal E.coli colonizes the intestine is not understood. In this NIH-funded laboratory, researchers use DNA microarrays and genetics to unravel the carbon nutrition of E. coli colonized in the mouse intestine. It has recently been shown that gastrointestinal pathogens are able to infect healthy individuals by competing for a different set of nutrients than do the harmless members of our normal commensal microbiota.
Dr. Bruce Roe - The Advanced Center for Genome Technology (ACGT) at the University of Oklahoma's Chemistry Department has been a designated Genome Center by the National Institutes of Health, National Human Genome Research Institute (NIH-NHGRI) since 1990 and is one of the first three laboratories involved in the world-wide Human Genome Project. Since then the ACGT has mapped (sequenced) the first completed human chromosome, human chromosome 22, discovering the genes involved in several forms of mental retardation, brain cancer, leukemia and schizophrenia. ACGT's research presently is funded by grants from the National Institutes of Health, National Human Genome Research Institute, National Science Foundation, Department of Energy, US Department of Agriculture and the Noble Foundation.
Dr. David Schmidtke - Assistant Professor, School of Chemical, Biological and Materials Engineering. Dr. Schmidtke's research interests are in the design and development of new analytical devices and technologies for medical therapy, and lie at the interface of medicine and engineering. His current research can be divided into three research directions: 1. Cell Adhesion; 2. Microfabrication; and 3. Biosensors.